| 名稱 | TP53 p.R280K Reference Standard 標(biāo)準(zhǔn)品 |
| 型號 | CBP10186 |
| 報(bào)價(jià) |  |
| 特點(diǎn) | TP53 p.R280K Reference Standard |
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基因檢測標(biāo)準(zhǔn)品 > Mutation > CBP10186TP53 p.R280K Reference Standard 標(biāo)準(zhǔn)品
- 詳細(xì)內(nèi)容
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CBP10186 | |
| Format | Genomic DNA |
| Description | TP53 R280K lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). R280K results in decreased activation and repression of wild-type Tp53 target genes (PMID: 17070499, PMID: 16322760, PMID: 18472962), as well as a gain-of-function in activation of novel targets, and leads to increased cell migration and invasion, and increased cell survival (PMID: 18472962, PMID: 24763051). |
| Technical Data | |
| DNA Change | c.839G>A |
| AA Change | p.R280K |
| Mutation type | Substitution - Missense |
| Zygosity | Homozygous |
| Allelic Frequency | 100% |
| Transcript | ENST00000269305 |
| Cosmic ID | COSM10728 |
| Chr position(GRCh37) | chr17:7577099 |
| Buffer | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing | Download for COA |
| Storage | 4℃ |
| Expiry | 36 months from the date of manufacture |
